Ogle G D, Rosenberg A R, Kainer G
Department of Nephrology, Prince of Wales Children's Hospital, Randwick, Sydney, Australia.
Pediatr Nephrol. 1992 Sep;6(5):483-9. doi: 10.1007/BF00874021.
Growth hormone (GH), either directly or through insulin-like growth factor-1 (IGF-1), has a wide spectrum of physiological and renal effects. This review concentrates on the effects of GH (derived from either pituitary or recombinant technology) and IGF-1 in three main areas: (1) sodium and water homeostasis; (2) calcium and phosphate balance, bone density and interactions with mineral regulating hormones; (3) fat and lean body mass. Observations of physiological changes in states of GH deficiency and excess in humans and animal models are presented. The lack of long-term toxicological data indicates that GH treatment for short stature in non-GH deficient children, with or without renal disease, should proceed with caution.
