[淋巴芯片技术研究进展及其应用]

[Advance in research on lymphochip technology and its application].

作者信息

Chen Xi-Lin, Zhang Wei-Jing

机构信息

Department of Oncology, Affiliated Hospital, Academy of Military Medical Sciences, Beijing 100039, China.

出版信息

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2003 Oct;11(5):553-6.

PMID:14575559

Abstract

The lymphochip is a special DNA chip which is used to monitor the gene expression profiling of malignant lymphoma. The basic principle, technological procedure and types of lymphochip were briefly reviewed in the article. The article emphatically introduced the advance of lymphochip implication which was used to identify the molecular diagnosis, distinguish the subtypes and research the morbific mechanism of malignant lymphoma. The aspects of development and problems in lymphochip study were discussed.

摘要

淋巴芯片是一种用于监测恶性淋巴瘤基因表达谱的特殊DNA芯片。本文简要回顾了淋巴芯片的基本原理、技术流程和类型。文章着重介绍了淋巴芯片在恶性淋巴瘤分子诊断、亚型鉴别及发病机制研究等方面应用的进展。同时探讨了淋巴芯片研究中的发展及存在的问题。