吗啡、纳洛酮和组胺系统对成年雄性大鼠水摄入量的影响。

Effect of morphine, naloxone and histamine system on water intake in adult male rats.

作者信息

Eidi Maryam, Oryan Shahrbanoo, Eidi Akram, Sepehrara Leili

机构信息

Department of Biology, Varamin Unit, Islamic Azad University, Varamin, Iran.

出版信息

Eur J Pharmacol. 2003 Oct 8;478(2-3):105-10. doi: 10.1016/j.ejphar.2003.07.001.

DOI:10.1016/j.ejphar.2003.07.001

PMID:14575794

Abstract

The present study investigated the interaction between histamine and opioid systems on water intake in adult male rats. Intracerebroventricular (i.c.v.) injections were carried out in all experiments. Water intake was measured 1 h after drug injections. Administration of histamine (40-80 microg/rat) and naloxone (0.5-1 microg/rat) increased, while morphine (2.5 microg/rat), pyrilamine (25-50 microg/rat), the histamine H1 receptor antagonist, and ranitidine (10-20 microg/rat), the histamine H2 receptor antagonist, decreased water intake in isolated rats. Blockade of histamine H1 and H2 receptors attenuated the histamine-induced response. Pyrilamine, but not ranitidine, increased the inhibitory effect induced by morphine. Also, pharmacological blockade of histamine H1 and H2 receptors decreased the naloxone-induced effect on water intake. It is concluded that the histaminergic system may have a close interaction with morphine and naloxone on drinking behavior.

摘要

本研究调查了组胺与阿片系统在成年雄性大鼠水摄入方面的相互作用。所有实验均进行脑室内（i.c.v.）注射。在药物注射1小时后测量水摄入量。给予组胺（40 - 80微克/只大鼠）和纳洛酮（0.5 - 1微克/只大鼠）会增加水摄入量，而吗啡（2.5微克/只大鼠）、组胺H1受体拮抗剂吡苄明（25 - 50微克/只大鼠）和组胺H2受体拮抗剂雷尼替丁（10 - 20微克/只大鼠）会减少隔离大鼠的水摄入量。组胺H1和H2受体的阻断减弱了组胺诱导的反应。吡苄明而非雷尼替丁增强了吗啡诱导的抑制作用。此外，组胺H1和H2受体的药理学阻断降低了纳洛酮对水摄入的影响。得出的结论是，组胺能系统在饮水行为方面可能与吗啡和纳洛酮有密切的相互作用。