降钙素基因相关肽和辣椒素敏感传入神经在中枢促甲状腺激素释放激素诱导的肝脏细胞保护中的作用。

Involvement of calcitonin gene-related peptide and capsaicin-sensitive afferents in central thyrotropin-releasing hormone-induced hepatic cytoprotection.

作者信息

Yoneda Masashi, Sato Yoichi, Nakamura Kimihide, Yokohama Shiro, Kono Toru, Watanobe Hajime, Terano Akira

机构信息

Department of Gastroenterology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Tochigi 321-0293, Japan.

出版信息

Eur J Pharmacol. 2003 Oct 8;478(2-3):173-7. doi: 10.1016/j.ejphar.2003.08.040.

DOI:10.1016/j.ejphar.2003.08.040

PMID:14575802

Abstract

The involvement of capsaicin-sensitive afferent neurons and calcitonin gene-related peptide (CGRP) in central thyrotropin-releasing hormone (TRH)-induced hepatic cytoprotection was investigated in rats. Both systemic capsaicin pretreatment and intravenous administration of CGRP receptor antagonist, human CGRP-(8-37), completely abolished the protective effect of intracisternal TRH analog (RX-77368; p-Glu-His-(3,3'-dimethyl)-Pro-NH2, 5 ng) against carbon tetrachloride (CCl4)-induced acute liver injury, assessed by serum alanin aminotransferase levels and histological changes. These data demonstrate the involvement of capsaicin-sensitive afferent neurons and CGRP in central TRH-induced hepatic cytoprotection.

摘要

在大鼠中研究了辣椒素敏感传入神经元和降钙素基因相关肽（CGRP）在中枢促甲状腺激素释放激素（TRH）诱导的肝脏细胞保护中的作用。全身性辣椒素预处理和静脉注射CGRP受体拮抗剂人CGRP-（8-37），均完全消除了脑池内TRH类似物（RX-77368；对-谷氨酸-组氨酸-（3,3'-二甲基）-脯氨酰胺，5 ng）对四氯化碳（CCl4）诱导的急性肝损伤的保护作用，该保护作用通过血清丙氨酸转氨酶水平和组织学变化来评估。这些数据表明辣椒素敏感传入神经元和CGRP参与了中枢TRH诱导的肝脏细胞保护。