Sadeghi Mahmoud, Daniel Volker, Wiesel Manfred, Hergesell Olaf, Opelz Gerhard
Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany. mahmoud.sadeghi@ med.uni-heidelberg.de.
Transplantation. 2003 Oct 27;76(8):1190-4. doi: 10.1097/01.TP.0000090345.19569.F3.
Chronic allograft nephropathy is an important cause of late renal transplant failure. Although numerous studies on cytokines have been carried out, the pathogenetic role of cytokines in chronic renal allograft nephropathy remains unclear.
In a retrospective study, the authors compared posttransplant plasma and urine cytokine levels (interleukin [IL]-1alpha, IL-1beta, soluble [s] IL-1 receptor [R] antagonist [A], IL-2, sIL-2R, IL-3, IL-4, IL-6, sIL-6R, IL-10, tumor necrosis factor-alpha, transforming growth factor-beta2, and interferon-gamma) in 34 matched pairs of patients with or without late graft failure and in 50 matched pairs with either normal or increased serum creatinine levels and continued stable graft function.
Twelve and 6 months before late graft failure, urine levels of sIL-6R were significantly increased (P=0.003 and P=0.01, respectively). Serum creatinine levels were not associated with increased urine sIL-6R.
High urine sIL-6R appears to be predictive of late graft failure in renal transplant recipients.
慢性移植肾肾病是肾移植后期失败的重要原因。尽管已经开展了大量关于细胞因子的研究，但细胞因子在慢性移植肾肾病发病机制中的作用仍不清楚。
在一项回顾性研究中，作者比较了34对匹配的有或无移植后期失败的患者以及50对血清肌酐水平正常或升高且移植肾功能持续稳定的匹配患者移植后的血浆和尿液细胞因子水平（白细胞介素[IL]-1α、IL-1β、可溶性[s]IL-1受体[R]拮抗剂[A]、IL-2、sIL-2R、IL-3、IL-4、IL-6、sIL-6R、IL-10、肿瘤坏死因子-α、转化生长因子-β2和干扰素-γ）。
在移植后期失败前12个月和6个月，尿液中sIL-6R水平显著升高（分别为P = 0.003和P = 0.01）。血清肌酐水平与尿液sIL-6R升高无关。
高尿液sIL-6R似乎可预测肾移植受者的移植后期失败。
