高尿可溶性白细胞介素-6受体作为肾移植受者移植肾晚期失功的预测指标。

High urine sIL-6R as a predictor of late graft failure in renal transplant recipients.

作者信息

Sadeghi Mahmoud, Daniel Volker, Wiesel Manfred, Hergesell Olaf, Opelz Gerhard

机构信息

Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany. mahmoud.sadeghi@ med.uni-heidelberg.de.

出版信息

Transplantation. 2003 Oct 27;76(8):1190-4. doi: 10.1097/01.TP.0000090345.19569.F3.

DOI:10.1097/01.TP.0000090345.19569.F3

PMID:14578752

Abstract

BACKGROUND

Chronic allograft nephropathy is an important cause of late renal transplant failure. Although numerous studies on cytokines have been carried out, the pathogenetic role of cytokines in chronic renal allograft nephropathy remains unclear.

METHODS

In a retrospective study, the authors compared posttransplant plasma and urine cytokine levels (interleukin [IL]-1alpha, IL-1beta, soluble [s] IL-1 receptor [R] antagonist [A], IL-2, sIL-2R, IL-3, IL-4, IL-6, sIL-6R, IL-10, tumor necrosis factor-alpha, transforming growth factor-beta2, and interferon-gamma) in 34 matched pairs of patients with or without late graft failure and in 50 matched pairs with either normal or increased serum creatinine levels and continued stable graft function.

RESULTS

Twelve and 6 months before late graft failure, urine levels of sIL-6R were significantly increased (P=0.003 and P=0.01, respectively). Serum creatinine levels were not associated with increased urine sIL-6R.

CONCLUSION

High urine sIL-6R appears to be predictive of late graft failure in renal transplant recipients.

摘要

背景

慢性移植肾肾病是肾移植后期失败的重要原因。尽管已经开展了大量关于细胞因子的研究，但细胞因子在慢性移植肾肾病发病机制中的作用仍不清楚。

方法

在一项回顾性研究中，作者比较了34对匹配的有或无移植后期失败的患者以及50对血清肌酐水平正常或升高且移植肾功能持续稳定的匹配患者移植后的血浆和尿液细胞因子水平（白细胞介素[IL]-1α、IL-1β、可溶性[s]IL-1受体[R]拮抗剂[A]、IL-2、sIL-2R、IL-3、IL-4、IL-6、sIL-6R、IL-10、肿瘤坏死因子-α、转化生长因子-β2和干扰素-γ）。