饮食失调与情绪障碍聚集性的家族研究。

Family study of the aggregation of eating disorders and mood disorders.

作者信息

Mangweth B, Hudson J I, Pope H G, Hausmann A, De Col C, Laird N M, Beibl W, Tsuang M T

机构信息

Department of Psychiatry, University of Innsbruck, Innsbruck University Clinics, Innsbruck, Austria.

出版信息

Psychol Med. 2003 Oct;33(7):1319-23. doi: 10.1017/s0033291703008250.

DOI:10.1017/s0033291703008250

PMID:14580085

Abstract

BACKGROUND

Family studies have suggested that eating disorders and mood disorders may coaggregate in families. To study further this question, data from a family interview study of probands with and without major depressive disorder was examined.

METHOD

A bivariate proband predictive logistic regression model was applied to data from a family interview study, conducted in Innsbruck, Austria, of probands with (N = 64) and without (N = 58) major depressive disorder, together with 330 of their first-degree relatives.

RESULTS

The estimated odds ratio (OR) for the familial aggregation of eating disorders (anorexia nervosa, bulimia nervosa and binge-eating disorder) was 7.0 (95 % CI 1.4, 28; P = 0.006); the OR for the familial aggregation of mood disorders (major depression and bipolar disorder) was 2.2 (0.92, 5.4; P = 0.076); and for the familial coaggregation of eating disorders with mood disorders the OR was 2.2 (1.1, 4.6; P = 0.035).

CONCLUSIONS

The familial coaggregation of eating disorders with mood disorders was significant and of the same magnitude as the aggregation of mood disorders alone--suggesting that eating disorders and mood disorders have common familial causal factors.

摘要

背景

家族研究表明，饮食失调和情绪失调可能在家族中共同聚集。为了进一步研究这个问题，我们检查了一项针对患有和未患有重度抑郁症的先证者的家族访谈研究的数据。

方法

采用双变量先证者预测逻辑回归模型，对在奥地利因斯布鲁克进行的一项家族访谈研究的数据进行分析。该研究纳入了患有重度抑郁症（N = 64）和未患有重度抑郁症（N = 58）的先证者，以及他们的330名一级亲属。

结果

饮食失调（神经性厌食症、神经性贪食症和暴饮暴食症）家族聚集的估计比值比（OR）为7.0（95%可信区间1.4, 28；P = 0.006）；情绪失调（重度抑郁症和双相情感障碍）家族聚集的OR为2.2（0.92, 5.4；P = 0.076）；饮食失调与情绪失调家族共同聚集的OR为2.2（1.1, 4.6；P = 0.035）。