Syrkin A L, Kukes V G, Poltavskaia M G, Andreev D A, Aref'eva A B, Teplonogova E V, Konova I A, Rykova M S
Ter Arkh. 2003;75(9):73-7.
To compare effects of metoprolol CR/XL and carvedilol on global and regional contractility of the left ventricle in patients with chronic cardiac failure (CCF).
The results of two trials were compared: the effects of metoprolol CR/XL and on carvedilol left ventricular contractility in patients with chronic cardiac failure (CCF). A total of 52 patients with ischemic heart disease (IHD) and dilated cardiomyopathy (DCMP) entered the studies. Of them, the treatment was completed in 19 and 20 patients, respectively. Ejection fraction (EF), left ventricular end systolic and diastolic volumes were measured at radionuclide ventriculography before and 6 months after the start of the treatment.
Both beta-blockers significantly increased EF and reduced the volumes. In both groups the rise of contractility in EF < 30% was similar. EF augmentation in patients with DCMP was greater than that in patients with IHD and depended on improvement of segmental contractility.
Significant differences were not found in the action of two beta-blockers on global and regional contractility of the left ventricle in patients with CCF.
比较美托洛尔缓释片/控释片与卡维地洛对慢性心力衰竭（CCF）患者左心室整体和局部收缩功能的影响。
比较两项试验结果：美托洛尔缓释片/控释片与卡维地洛对慢性心力衰竭（CCF）患者左心室收缩功能的影响。共有52例缺血性心脏病（IHD）和扩张型心肌病（DCMP）患者进入研究。其中，分别有19例和20例患者完成治疗。在治疗开始前及开始后6个月进行放射性核素心室造影，测量射血分数（EF）、左心室收缩末期和舒张末期容积。
两种β受体阻滞剂均显著提高EF并减小容积。两组中EF<30%患者的收缩功能增强相似。DCMP患者的EF增加大于IHD患者，且取决于节段性收缩功能的改善。
在CCF患者中，两种β受体阻滞剂对左心室整体和局部收缩功能的作用未发现显著差异。
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