Rerolle J Ph, Helal I, Morelon E
Service de transplantation rénale, Hôpital Necker, Paris.
Nephrologie. 2003;24(6):309-15.
Despite improvements in the management of transplanted patients, viral infections following transplantation remain significant causes of morbidity and mortality. New laboratory techniques have improved the diagnosis of pathogenic viral infections following transplantation such as parvovirus B19 infections. Anemia is the principal abnormality associated with parvovirus B19 infection but other complications have been reported such as hepatitis, glomerulonephritis, myocarditis or arthritis. In immunocompromised patients, infection, which may remain undiagnosed by serological tests is usually assessed by PCR. Patients may spontaneously recover. However, in the absence of specific antiviral therapy, intravenous immunoglobulin appears to be the more efficacious treatment.
尽管移植患者的管理有所改善,但移植后的病毒感染仍然是发病和死亡的重要原因。新的实验室技术提高了移植后致病性病毒感染的诊断水平,如细小病毒B19感染。贫血是与细小病毒B19感染相关的主要异常情况,但也有其他并发症的报道,如肝炎、肾小球肾炎、心肌炎或关节炎。在免疫功能低下的患者中,血清学检测可能无法诊断的感染通常通过聚合酶链反应(PCR)进行评估。患者可能会自发康复。然而,在没有特异性抗病毒治疗的情况下,静脉注射免疫球蛋白似乎是更有效的治疗方法。