一种强效且选择性的 5-羟色胺（5-HT）6 拮抗剂的鉴定：由 2-(苯磺酰基)-3,3-双(甲硫基)丙烯腈一步合成(E)-3-(苯磺酰基)-2-(甲硫基)吡啶并[1,2-a]嘧啶-4-亚胺。
Identification of a potent and selective 5-HT(6) antagonist: one-step synthesis of (E)-3-(benzenesulfonyl)-2- (methylsulfanyl)pyrido[1,2-a]pyrimidin-4-ylidenamine from 2-(benzenesulfonyl)-3,3-bis(methylsulfanyl)acrylonitrile.
作者信息
Wu Yong-Jin, He Huan, Hu Shuanghua, Huang Yazhong, Scola Paul M, Grant-Young Katharine, Bertekap Robert L, Wu Dedong, Gao Qi, Li Yi, Klakouski Cheryl, Westphal Ryan S
机构信息
Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, Connecticut 06492, USA.
出版信息
J Med Chem. 2003 Nov 6;46(23):4834-7. doi: 10.1021/jm034142q.
PMID:14584934
Abstract
(E)-3-(Benzenesulfonyl)-2-(methylsulfanyl)pyrido[1,2-a]pyrimidin-4-ylidenamine (7) was found to be a potent and selective 5-HT(6) antagonist. A one-step synthesis of this compound is described.
摘要
发现(E)-3-(苯磺酰基)-2-(甲硫基)吡啶并[1,2-a]嘧啶-4-亚胺(7)是一种强效且选择性的5-羟色胺(6)拮抗剂。本文描述了该化合物的一步合成方法。
Zotero 插件