过氧化物酶体增殖物激活受体（PPAR）γ激活剂对实验性新月体性肾小球肾炎的抑制作用
Suppression of experimental crescentic glomerulonephritis by peroxisome proliferator-activated receptor (PPAR)gamma activators.
作者信息
Haraguchi Kazutaka, Shimura Hiroki, Onaya Toshimasa
机构信息
Third Department of Internal Medicine, Yamanashi Medical University, 1110 Tamaho, Nakakoma, Yamanashi 409-3898, Japan.
出版信息
Clin Exp Nephrol. 2003 Mar;7(1):27-32. doi: 10.1007/s101570300003.
BACKGROUND
It has been recently reported that peroxisome proliferator-activated receptors (PPARs)gamma exist in various tissues and that they exibit anti-inflammatory effects.
METHODS
We investigated the effects of PPARgamma activators on the development of crescentic glomerulonephritis. Crescentic glomerulonephritis was induced by the injection of rabbit anti-rat glomerular basement membrane antibody in WKY rats.
RESULTS
Administration of troglitazone suppressed urinary protein excretion and crescent formation as indicated by crescent scores. Pioglitazone, a PPARgamma activator, mimicked the effect of troglitazone, but bezafibrate, a PPARalpha-activator, did not. Immunohistology revealed that troglitazone and pioglitazone inhibited the infiltration of ED-1-positive monocyte/macrophages and CD8-positive cells into glomeruli.
CONCLUSIONS
In the present study, we demonstrated that PPARgamma activators exert antinephritic effects by suppressing the recruitment of inflammatory cells via a PPARgamma-dependent mechanism.
背景
最近有报道称，过氧化物酶体增殖物激活受体（PPARs）γ存在于多种组织中，并具有抗炎作用。
方法
我们研究了PPARγ激活剂对新月体性肾小球肾炎发展的影响。通过向WKY大鼠注射兔抗大鼠肾小球基底膜抗体诱导新月体性肾小球肾炎。
结果
如新月体评分所示，曲格列酮给药可抑制尿蛋白排泄和新月体形成。PPARγ激活剂吡格列酮模拟了曲格列酮的作用，但PPARα激活剂苯扎贝特则没有。免疫组织学显示，曲格列酮和吡格列酮可抑制ED-1阳性单核细胞/巨噬细胞和CD8阳性细胞浸润到肾小球中。
结论
在本研究中，我们证明PPARγ激活剂通过PPARγ依赖性机制抑制炎症细胞募集，从而发挥抗肾炎作用。
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