大鼠高苯丙氨酸血症的一种新实验模型。对氯苯丙氨酸和复方新诺明的作用。
A new experimental model of hyperphenylalaninemia in rat. Effect of p-chlorophenylalanine and cotrimoxazole.
作者信息
Dhondt J L, Dautrevaux M, Biserte G, Farriaux J P
出版信息
Biochimie. 1977;59(8-9):713-7. doi: 10.1016/s0300-9084(77)80250-2.
A new experimental model of hyperphenylalaninemia was proposed. Combination of p.chlorophenylalanine, strongly inhibitor of phenylalanine hydroxylase, and cotrimoxazole, presumably inhibitor of dihydropteridine reductase, produced a good inhibition of phenylalanine hydroxylation in vivo. Thus phenylalaninemia reached values similar to those found in PKU patients, without administration of excess phenylalanine. Tyrosine concentrations remained near the control values and a phenylketonuria occurred.
提出了一种新的高苯丙氨酸血症实验模型。苯丙氨酸羟化酶的强抑制剂对氯苯丙氨酸与可能的二氢蝶啶还原酶抑制剂复方新诺明联合使用，在体内对苯丙氨酸羟化产生了良好的抑制作用。因此，在不给予过量苯丙氨酸的情况下，苯丙氨酸血症达到了与苯丙酮尿症患者相似的值。酪氨酸浓度保持在接近对照值的水平，并发生了苯丙酮尿症。
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