Mulero M, Fernández Raigoso P, Vázquez J, Lamelas M L, Corte D, Allende M T, Rodríguez J C, Vizoso F
Medicina de Familia y Comunitaria del Hospital Central de Asturias. Oviedo. Asturias. Spain.
Rev Esp Med Nucl. 2003 Nov;22(6):386-94. doi: 10.1016/s0212-6982(03)72222-8.
To determine the content of epidermal growth factor receptor (EGFR) using a radioligand method in breast cancer and to analyze the relationship between the EGFR levels and the characteristics of patients and tumors. Prognostic significance was also analyzed.
EGFR was measured by a single point radioligand assay in 265 invasive breast carcinomas tissues. In addition, estrogen and progesterone receptors (ER and PR) were measured by enzymatic immunoassays. We analyze the relationship of EGFR levels with the different clinico-pathologic parameters.
EGFR levels in breast carcinomas varied widely (0.1 to 403) with a median at 4 fmol/mg prot. The significantly higher concentrations of EGFR were detected in patients under 60 years old (p = 0.042), undifferentiated tumors (p = 0.04), and carcinomas with negative ER and PR (p < 0.019 y p < 0018, respectively). In addition, there was a negative correlation between EGFR and the ER and PR levels (p < 0.05). EGFR levels did not show any relationship with the patient's prognosis.
In addition, intratumoral levels of EGFR in breast carcinomas vary widely and the highest concentrations are associated with the most aggresive characteristics of the tumor.
采用放射性配体法测定乳腺癌组织中表皮生长因子受体（EGFR）的含量，并分析EGFR水平与患者及肿瘤特征之间的关系。同时分析其预后意义。
采用单点放射性配体分析法检测265例浸润性乳腺癌组织中的EGFR。此外，采用酶免疫分析法检测雌激素和孕激素受体（ER和PR）。分析EGFR水平与不同临床病理参数之间的关系。
乳腺癌组织中EGFR水平差异很大（0.1至403），中位数为4 fmol/mg蛋白。在60岁以下患者（p = 0.042）、未分化肿瘤（p = 0.04）以及ER和PR均为阴性的癌组织中（分别为p < 0.019和p < 0.018）检测到EGFR浓度显著更高。此外，EGFR与ER和PR水平呈负相关（p < 0.05）。EGFR水平与患者预后无任何关系。
此外，乳腺癌组织内EGFR水平差异很大，最高浓度与肿瘤最具侵袭性的特征相关。
