产后神经发育障碍：在突触处相遇？

Postnatal neurodevelopmental disorders: meeting at the synapse?

作者信息

Zoghbi Huda Y

机构信息

Departments of Pediatrics, Neurology, and Molecular and Human Genetics, Division of Neuroscience, and Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA.

出版信息

Science. 2003 Oct 31;302(5646):826-30. doi: 10.1126/science.1089071.

DOI:10.1126/science.1089071

PMID:14593168

Abstract

We often think of neurodevelopmental disorders as beginning before birth, and many certainly do. A handful, however, strike many months after birth, following a period of apparently normal growth and development. Autism and Rett syndrome are two such disorders, and here I consider some of their similarities at the phenotypic and pathogenic levels. I propose that both disorders result from disruption of postnatal or experience-dependent synaptic plasticity.

摘要

我们常常认为神经发育障碍始于出生前，许多情况确实如此。然而，有少数情况是在出生后数月才出现，此前有一段明显正常的生长和发育时期。自闭症和雷特综合征就是这样的两种疾病，在此我将探讨它们在表型和致病层面的一些相似之处。我提出这两种疾病都是由出生后或依赖经验的突触可塑性破坏所致。