Mess Sarah A, Kim Sylvia, Davison Steven, Heckler Fred
Division of Plastic Surgery, Georgetown University Hospital, Washington, DC 2002, USA.
Ann Plast Surg. 2003 Nov;51(5):465-7. doi: 10.1097/01.SAP.0000070645.30682.93.
Currently, the success of ulcer treatment is limited by the high recurrence and complication rates. Spasticity is an important contributing factor to ulcer recurrence, and intrathecal baclofen is an effective method to reduce spasticity. Spasticity creates friction, shear, and mobility impairment resulting in wound dehiscence, flap loss, infection, and hematoma. Spasticity can be managed pharmacologically and surgically; baclofen is the drug of choice. Baclofen inhibits spasticity by blocking excitatory neurotransmitters in the spinal dorsal horn. Intrathecal baclofen maximizes the dose delivered to spinal receptors and minimizes the side effects associated with oral baclofen. Case reports of intrathecal baclofen used in patients with pressure sores demonstrate the use of intrathecal baclofen to improve reconstructive outcomes in spastic patients.
目前,溃疡治疗的成功率受到高复发率和并发症发生率的限制。痉挛是溃疡复发的一个重要促成因素,鞘内注射巴氯芬是减轻痉挛的有效方法。痉挛会产生摩擦、剪切力和活动障碍,导致伤口裂开、皮瓣坏死、感染和血肿。痉挛可以通过药物和手术进行控制;巴氯芬是首选药物。巴氯芬通过阻断脊髓背角的兴奋性神经递质来抑制痉挛。鞘内注射巴氯芬可使输送至脊髓受体的剂量最大化,并将与口服巴氯芬相关的副作用降至最低。关于鞘内注射巴氯芬用于压疮患者的病例报告表明,鞘内注射巴氯芬可改善痉挛患者的重建效果。