家族性自身免疫作为系统性红斑狼疮的一个风险因素及反之亦然：一项病例对照研究。

Familial autoimmunity as a risk factor for systemic lupus erythematosus and vice versa: a case-control study.

作者信息

Priori R, Medda E, Conti F, Cassara E A M, Danieli M G, Gerli R, Giacomelli R, Franceschini F, Manfredi A, Pietrogrande M, Stazi M A, Valesini G

机构信息

Divisione di Reumatologia, Dipartimento di Terapia Medica Applicata, Università degli Studi La Sapienza, Rome, Italy.

出版信息

Lupus. 2003;12(10):735-40. doi: 10.1191/0961203303lu457oa.

DOI:10.1191/0961203303lu457oa

PMID:14596421

Abstract

The objective of this multicentric case-control study was to investigate if a history of autoimmune disease (AD) in first-degree relatives (FDR) is a risk factor for systemic lupus erythematosus (SLE) and to evaluate the risk of AD among FDR of SLE patients. Cases were Italian SLE patients consecutively enrolled. Controls were orthopaedic inpatients without any autoimmune diseases. The strength of the association between family history of AD and SLE was measured as an odds ratio (OR) calculated from the coefficient of an unconditional regression model. To calculate the risk of AD among FDR of SLE patients, the extended generalized estimating equation technique was used. In total, 154 SLE cases and 140 controls were enrolled. A family history of AD was reported by 22.7% of SLE patients and by 5.7% of the controls. The risk of SLE increased with the number of FDR with AD (one FDR affected, OR = 4.1; two or more, OR = 11.3). The probability of having AD was higher among FDR of SLE cases in comparison to FDR of controls (RR = 4.6; 95%CI 1.9-11.1). A female SLE patient conferred an increased risk of AD to her FDR; this risk is doubled in females (OR 10.3; 95% CI 3.1-34.4).

摘要

这项多中心病例对照研究的目的是调查一级亲属（FDR）中自身免疫性疾病（AD）史是否是系统性红斑狼疮（SLE）的危险因素，并评估SLE患者的FDR中患AD的风险。病例为连续纳入的意大利SLE患者。对照为无任何自身免疫性疾病的骨科住院患者。AD家族史与SLE之间关联的强度通过无条件回归模型系数计算的比值比（OR）来衡量。为计算SLE患者的FDR中患AD的风险，采用了扩展广义估计方程技术。总共纳入了154例SLE病例和140例对照。22.7%的SLE患者和5.7%的对照报告有AD家族史。SLE的风险随着患AD的FDR数量增加而增加（一名FDR患病，OR = 4.1；两名或更多，OR = 11.3）。与对照的FDR相比，SLE病例的FDR患AD的概率更高（RR = 4.6；95%CI 1.9 - 11.1）。女性SLE患者会使其FDR患AD的风险增加；女性的这种风险会加倍（OR 10.3；95%CI 3.1 - 34.4）。