Gardner Julie Meeks, Walker Susan P, Powell Christine A, Grantham-McGregor Sally
Epidemiology Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Kingston, Jamaica.
J Pediatr. 2003 Nov;143(5):634-9. doi: 10.1067/S0022-3476(03)00455-4.
To determine whether early psychosocial intervention with low birth weight term (LBW-T) infants improved cognition and behavior and to compare LBW-T with normal birth weight (NBW) infants.
A randomized controlled trial was carried out in Kingston, Jamaica, with 140 LBW-T infants (weight<2500 g). The intervention comprised weekly home visits by paraprofessionals for the first 8 weeks of life aimed at improving maternal-child interaction. LBW-T and 94 matched NBW (weight 2500 to 4000 g) infants were recruited from the main maternity hospital. Main outcome measures were problem solving (2 means-end tests: cover and support) and 4 behavior ratings at 7 months. Analyses used were the t test for intervention effects and multiple regression to compare LBW and NBW infants.
LBW-T intervened infants had higher scores than LBW-T control infants on the cover test (P<.05) and were more cooperative (P<.01) and happy (P<.05). LBW-T control infants had poorer scores on both the cover (P<.001) and support tests (P<.01), vocalized less (P<.02), and were less cooperative (P<.001), happy (P<.02), and active (P<.02) than NBW infants. LBW-T intervened infants had lower scores than NBW infants only on the support test (P<.05).
Early low-cost intervention can improve cognition and behavior of LBW-T infants in developing countries.
确定对足月低体重(LBW-T)婴儿进行早期心理社会干预是否能改善其认知和行为,并将LBW-T婴儿与正常出生体重(NBW)婴儿进行比较。
在牙买加金斯敦进行了一项随机对照试验,纳入了140名LBW-T婴儿(体重<2500克)。干预措施包括在婴儿出生后的前8周由准专业人员每周进行家访,旨在改善母婴互动。从主要妇产医院招募了LBW-T婴儿和94名匹配的NBW婴儿(体重2500至4000克)。主要结局指标为7个月时的问题解决能力(两项手段-目的测试:遮盖和支撑)和4项行为评分。所采用的分析方法为干预效果的t检验以及用于比较LBW和NBW婴儿的多元回归分析。
接受干预的LBW-T婴儿在遮盖测试中的得分高于LBW-T对照组婴儿(P<.05),且更合作(P<.01)、更快乐(P<.05)。LBW-T对照组婴儿在遮盖测试(P<.001)和支撑测试(P<.01)中的得分均较低,发声较少(P<.02),与NBW婴儿相比,合作性较差(P<.001)、快乐程度较低(P<.02)且活跃度较低(P<.02)。仅在支撑测试中,接受干预的LBW-T婴儿得分低于NBW婴儿(P<.05)。
在发展中国家,早期低成本干预可改善LBW-T婴儿的认知和行为。