Carmenini G, Martusciello S, Di Maio F, Scioli A, Nicoletti M, Meloni F
Instituto di I Clinica medica, Università La Sapienza, Roma.
Recenti Prog Med. 1992 Oct;83(10):559-63.
The authors report a case of Horton's arteritis in a woman (aged 76) presented some peculiarities. The arteritis simultaneously interested both superficial temporal arteries; in a second time caused a bilateral "claudicatio masticationis"; induced a worsening of extrapyramidal symptoms from which the patient had been suffering for many years, due to the possible involvement also of the endocranial arteries. The histologic picture on a biopsy of the left temporal artery was typical of the Horton's disease, but without giant cells; the authors suppose that this is due to a therapy with FANS administered before carrying out the biopsy. The patient was treated with cortisone per os at a low dosage, causing a quick regression of the symptoms and a normalization of the laboratory tests. Also this result differs from what most authors have observed: they maintain that Horton's arteritis has become rather resistant to the cortisone therapy and required high dosage for a very long time. The authors maintain that precocity of diagnosis and an immediate treatment can influence in a significant way the course of the disease.
作者报告了一例76岁女性霍顿动脉炎病例,该病例呈现出一些特殊之处。动脉炎同时累及双侧颞浅动脉;其次引发了双侧“咀嚼肌跛行”;由于可能累及颅内动脉,导致患者多年来一直遭受的锥体外系症状加重。左侧颞动脉活检的组织学表现是典型的霍顿病,但无巨细胞;作者推测这是由于在活检前使用了非甾体抗炎药治疗所致。患者接受了低剂量口服可的松治疗,症状迅速消退,实验室检查恢复正常。这一结果也与大多数作者观察到的情况不同:他们认为霍顿动脉炎对可的松治疗已相当耐药,需要长时间使用高剂量药物。作者认为早期诊断和立即治疗能显著影响疾病进程。