[Visceral hypersensitivity of the large intestine mucosa in patients with irritable bowel syndrome--cause of the non-inflammatory changes in the pain syndrome].

The purpose of our research was to reveal the existence of an association between clinical expressions of visceral hypersensitivity--the intensity of abdominal pain and nature of endoscopic changes in the large intestine in patients with the irritable bowel syndrome (IBS). It was established that there was a direct association between the intensity of the pain syndrome and existence of endoscopic changes in the large intestine mucous coat. The macroscopic picture regarded as an inflammation of the mucous coat in patients with the IBS is not confirmed with the data of morphological research. The presence of endoscopic features of inflammation is not favorable from the prognostic point of view for deletion of abdominal pain in patients who undergo therapy with selective antagonists of calcium.