In an aging society, chronic pain will increasingly have a significant impact on successful aging. Chronic pain may further differentially affect racial and ethnic minorities while diminishing their health and quality of life. This study addresses the potential differential effects of chronic pain cross-culturally in older Americans. A retrospective analysis of a group of subjects presenting for chronic pain management in a tertiary care multidisciplinary pain center was performed. This comparative study of black and white American adults (N [equals] 2040) was done to determine whether there were differences in (1). psychologic functioning, (2). pain characteristics, (3). pain disability, and (4). comorbidities. The black American population had more depressive symptoms and symptoms of posttraumatic stress disorder when compared with the white Americans. These results suggest that chronic pain adversely affects the quality of life and health status of black Americans to a greater extent than white Americans before initial presentation for treatment at a multidisciplinary pain center. This study of older Americans with chronic pain showed significant differences in pain and health status based on race. It further demonstrates a difference in the chronic pain experience based on race in older Americans.