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基因组双胞胎研究计划:一种识别基因对健康和疾病影响的策略。

GenomEUtwin: a strategy to identify genetic influences on health and disease.

作者信息

Peltonen Leena

机构信息

Department of Medical Genetics, University of Helsinki and Department of Molecular Medicine, National Public Health Institute, Finland.

出版信息

Twin Res. 2003 Oct;6(5):354-60. doi: 10.1375/136905203770326358.

Abstract

In this issue of Twin Research, we describe different facets of a European Community funded effort, GenomEUtwin, which capitalises on eight of the world's largest and best characterised twin registers and a multi-national population cohort, MORGAM. This international study, reaching beyond the geographical borders of Europe, is based on linkage and association strategies designed to identify genetic contributors to health and disease using integrated expertise of participating groups in genetics, epidemiology and biostatistics. By merging information from numerous epidemiological and genetic databases, GenomEUtwin will create an intellectual and technical infrastructure for future genetic epidemiological studies aiming to define genetic and life style risks for common human diseases.

摘要

在本期《双生子研究》中,我们描述了一项由欧盟资助的研究项目GenomEUtwin的不同方面。该项目利用了全球八个最大且特征描述最完善的双生子登记数据库以及一个多国人群队列MORGAM。这项超越欧洲地理边界的国际研究,基于连锁和关联策略,旨在通过遗传学、流行病学和生物统计学领域参与团队的综合专业知识,识别健康和疾病的遗传因素。通过整合众多流行病学和遗传数据库的信息,GenomEUtwin将为未来旨在确定常见人类疾病的遗传和生活方式风险的遗传流行病学研究创建一个知识和技术基础设施。

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