缓激肽诱导的[Ca2+]i振荡参与K-ras转化成纤维细胞中磷脂酰胆碱的分解。
Involvement of bradykinin-induced [Ca2+]i oscillations in phosphatidylcholine breakdown in K-ras-transformed fibroblasts.
作者信息
Fu T, Okano Y, Nozawa Y
机构信息
Department of Biochemistry, Gifu University School of Medicine, Japan.
出版信息
Agents Actions Suppl. 1992;38 ( Pt 2):43-9.
PMID:1462844
Abstract
Bradykinin (BK) induced a biphasic 1,2-diacylglycerol production in both K-ras-transformed (DT) cells and its parent NIH3T3 cells. The first phase was coincident with the transient phosphoinositide turnover and the second sustained phase was derived from hydrolysis of phosphatidylcholine (PC). In DT cells, the PC breakdown was considerably due to phospholipase C and dependent on intracellular calcium oscillations.
摘要
缓激肽（BK）在K-ras转化的（DT）细胞及其亲本NIH3T3细胞中均诱导出双相的1,2-二酰基甘油生成。第一阶段与瞬时磷脂酰肌醇周转同时发生，第二持续阶段来源于磷脂酰胆碱（PC）的水解。在DT细胞中，PC的分解主要归因于磷脂酶C，并且依赖于细胞内钙振荡。
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