α1-蛋白酶抑制剂在半溶性葡聚糖诱导的抗出血中的作用。
The role of alpha 1-proteinase inhibitor in semisoluble glucan induced resistance to hemorrhage.
作者信息
Vereschagin E I, Korolenko T A, Arkhipov S A
机构信息
Department of Cellular Biochemistry and Physiology, Academy of Medical Sciences of USSR, Novosibirsk.
出版信息
Agents Actions Suppl. 1992;38 ( Pt 3):385-8.
The present study was undertaken to evaluate the mechanism of protective effect of semisoluble beta-1,3-carboxymethylglucan (CMG) during acute massive hemorrhage. CBA mice were injected i.v. with glucan (25 mg/kg) 24 h prior to hemorrhage (50% of blood circulating volume). Survival data indicated that glucan increased survival compared with control. However, alpha 1-proteinase inhibitor activity in serum have been even decreased 24 h after glucan administration. Moreover enhancement of active oxygen form production and leakage of cytosol and lysosomal enzymes after CMG application were noted.
本研究旨在评估半溶性β-1,3-羧甲基葡聚糖（CMG）在急性大量出血期间的保护作用机制。在出血（循环血量的50%）前24小时，给CBA小鼠静脉注射葡聚糖（25毫克/千克）。生存数据表明，与对照组相比，葡聚糖提高了生存率。然而，在给予葡聚糖24小时后，血清中的α1-蛋白酶抑制剂活性甚至有所下降。此外，还观察到应用CMG后活性氧形式的产生增加以及细胞质和溶酶体酶的泄漏。
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