Bartoli Sandra, Jensen Kim B, Kilburn Jeremy D
Department of Chemistry, University of Southampton, Southampton SO17 1BJ, UK.
J Org Chem. 2003 Nov 28;68(24):9416-22. doi: 10.1021/jo0348874.
The trifluoroacetyl moiety has been used as a new protecting group for guanidine functionality. The protecting group is easily cleaved under mild basic conditions and is complementary to the Boc, Cbz, and Ddpe protecting groups. The protecting group can be applied to peptide synthesis in solution as well as on a solid phase as it is orthogonal to a Boc and Cbz strategy and semiorthogonal to an Fmoc strategy.
三氟乙酰部分已被用作胍官能团的新型保护基团。该保护基团在温和的碱性条件下易于裂解，并且与Boc、Cbz和Ddpe保护基团互补。由于它与Boc和Cbz策略正交且与Fmoc策略半正交，因此该保护基团可应用于溶液中的肽合成以及固相肽合成。
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