钙黏蛋白和nectins在中间神经元突触形成中的作用。

The roles of cadherins and nectins in interneuronal synapse formation.

作者信息

Takai Yoshimi, Shimizu Kazuya, Ohtsuka Toshihisa

机构信息

Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine/Faculty of Medicine, Suita 565-0871, Japan.

出版信息

Curr Opin Neurobiol. 2003 Oct;13(5):520-6. doi: 10.1016/j.conb.2003.09.003.

DOI:10.1016/j.conb.2003.09.003

PMID:14630213

Abstract

Cadherins are Ca(2+)-dependent intercellular adhesion molecules (CAMs) and they play key roles in the intercellular junctions of a wide variety of cells, including interneuronal synapses. Nectins are Ca(2+)-independent immunoglobulin-like CAMs and they are also involved in the organization of various types of intercellular junctions, including interneuronal synapses, either in cooperation with or independently of cadherins. Intercellular adhesion through nectins induces activation of Cdc42 and Rac small G proteins, leading to a reorganization of the actin cytoskeleton, gene expression, and cell polarization.

摘要

钙黏蛋白是依赖钙离子的细胞间黏附分子（CAMs），它们在包括中间神经元突触在内的多种细胞的细胞间连接中发挥关键作用。NECTIN是不依赖钙离子的免疫球蛋白样CAMs，它们也参与各种类型细胞间连接的组织，包括中间神经元突触，与钙黏蛋白协同作用或独立于钙黏蛋白发挥作用。通过NECTIN的细胞间黏附诱导Cdc42和Rac小G蛋白的激活，导致肌动蛋白细胞骨架的重组、基因表达和细胞极化。