Abl家族激酶对神经元形态发生和突触功能的调控。

Regulation of neuronal morphogenesis and synaptic function by Abl family kinases.

作者信息

Moresco Eva M Y, Koleske Anthony J

机构信息

Department of Genetics, Yale School of Medicine, PO Box 208024, New Haven, CT 06520-8204, USA.

出版信息

Curr Opin Neurobiol. 2003 Oct;13(5):535-44. doi: 10.1016/j.conb.2003.08.002.

DOI:10.1016/j.conb.2003.08.002

PMID:14630215

Abstract

Recent studies provide insights into the mechanisms by which Abelson non-receptor tyrosine kinases relay information from axon guidance and growth factor receptors to promote cytoskeletal rearrangements in developing neurons. Abelson non-receptor tyrosine kinases are also found in mature synapses, where their activities are required for optimal synaptic function.

摘要

近期研究深入揭示了阿贝尔逊非受体酪氨酸激酶将轴突导向和生长因子受体的信息进行传递，从而促进发育中神经元细胞骨架重排的机制。在成熟突触中也发现了阿贝尔逊非受体酪氨酸激酶，其活性对于最佳突触功能是必需的。