Targeted conditional somatic mutagenesis in the mouse: temporally-controlled knock out of retinoid receptors in epidermal keratinocytes.

作者信息

Metzger Daniel, Indra Arup Kumar, Li Mei, Chapellier Benoit, Calleja Cécile, Ghyselinck Norbert B, Chambon Pierre

机构信息

Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Collège de France, BP 10142, 67404 Illkirch, France.

出版信息

Methods Enzymol. 2003;364:379-408. doi: 10.1016/s0076-6879(03)64022-x.

DOI:10.1016/s0076-6879(03)64022-x

PMID:14631857

Abstract

摘要

相似文献

Targeted conditional somatic mutagenesis in the mouse: temporally-controlled knock out of retinoid receptors in epidermal keratinocytes.

Methods Enzymol. 2003;364:379-408. doi: 10.1016/s0076-6879(03)64022-x.

RXR-alpha ablation in skin keratinocytes results in alopecia and epidermal alterations.

Development. 2001 Mar;128(5):675-88. doi: 10.1242/dev.128.5.675.

Conditional gene knockout using Cre recombinase.

Mol Biotechnol. 2001 Mar;17(3):269-75. doi: 10.1385/MB:17:3:269.

Overexpression of CRABPI in suprabasal keratinocytes enhances the proliferation of epidermal basal keratinocytes in mouse skin topically treated with all-trans retinoic acid.

Exp Cell Res. 2008 Jan 1;314(1):38-51. doi: 10.1016/j.yexcr.2007.07.016. Epub 2007 Jul 24.

Skin abnormalities generated by temporally controlled RXRalpha mutations in mouse epidermis.

Nature. 2000 Oct 5;407(6804):633-6. doi: 10.1038/35036595.

Suprabasal expression of a dominant-negative RXR alpha mutant in transgenic mouse epidermis impairs regulation of gene transcription and basal keratinocyte proliferation by RAR-selective retinoids.

Genes Dev. 1997 Jan 1;11(1):59-71. doi: 10.1101/gad.11.1.59.

Dominant-negative retinoic acid receptors elicit epidermal defects through a non-canonical pathway.

J Biol Chem. 2005 Jan 28;280(4):3012-21. doi: 10.1074/jbc.M411522200. Epub 2004 Nov 4.

Cracking conditional transgenesis.

Nat Rev Genet. 2001 Jan;2(1):7. doi: 10.1038/35047534.

Overexpression of retinoic acid receptors alpha and gamma into neoplastic epidermal cells causes retinoic acid-induced growth arrest and apoptosis.

Carcinogenesis. 2001 Dec;22(12):1955-63. doi: 10.1093/carcin/22.12.1955.

A conditional floxed (loxP-flanked) allele for the retinoic acid receptor alpha (RARalpha) gene.

Genesis. 2002 Feb;32(2):87-90. doi: 10.1002/gene.10071.

引用本文的文献

Advances in prostate cancer research models: From transgenic mice to tumor xenografting models.

Asian J Urol. 2016 Apr;3(2):64-74. doi: 10.1016/j.ajur.2016.02.004. Epub 2016 Mar 2.

Generation of CD4CreER(T²) transgenic mice to study development of peripheral CD4-T-cells.

Genesis. 2012 Dec;50(12):908-13. doi: 10.1002/dvg.22052. Epub 2012 Sep 12.

RXRα ablation in epidermal keratinocytes enhances UVR-induced DNA damage, apoptosis, and proliferation of keratinocytes and melanocytes.

J Invest Dermatol. 2011 Jan;131(1):177-87. doi: 10.1038/jid.2010.290. Epub 2010 Oct 14.

Glucocorticoid receptor regulates overlapping and differential gene subsets in developing and adult skin.

Mol Endocrinol. 2010 Nov;24(11):2166-78. doi: 10.1210/me.2010-0183. Epub 2010 Sep 29.

Loss of nuclear receptor RXRα in epidermal keratinocytes promotes the formation of Cdk4-activated invasive melanomas.

Pigment Cell Melanoma Res. 2010 Oct;23(5):635-48. doi: 10.1111/j.1755-148X.2010.00732.x. Epub 2010 Jul 9.

Function of retinoic acid receptors during embryonic development.

Nucl Recept Signal. 2009;7:e002. doi: 10.1621/nrs.07002. Epub 2009 Apr 3.

Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine.

Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6309-14. doi: 10.1073/pnas.0900427106. Epub 2009 Feb 27.

Temporally controlled ablation of PTEN in adult mouse prostate epithelium generates a model of invasive prostatic adenocarcinoma.

Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2521-6. doi: 10.1073/pnas.0712021105. Epub 2008 Feb 11.

Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes.

Genes Dev. 2006 Jun 1;20(11):1525-38. doi: 10.1101/gad.368706.

Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin.

Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14795-800. doi: 10.1073/pnas.0507385102. Epub 2005 Sep 30.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验