葡萄膜黑色素瘤的分子遗传学

Molecular genetics of uveal melanoma.

作者信息

Loercher Amy E, Harbour J William

机构信息

Department of Ophthalmology and Visual Sciences, Washington University, School of Medicine, St. Louis, MO 63110, USA.

出版信息

Curr Eye Res. 2003 Aug;27(2):69-74. doi: 10.1076/ceyr.27.2.69.15952.

DOI:10.1076/ceyr.27.2.69.15952

PMID:14632157

Abstract

In the past decade, there have been impressive advances in our understanding of chromosomal, genetic and molecular alterations that occur in uveal melanoma. Nevertheless, a coherent picture of the molecular pathogenesis of this eye cancer is yet to emerge. Herein, we review the findings to date, discuss the insights they provide, and suggest future directions for molecular research in uveal melanoma.

摘要

在过去十年中，我们对葡萄膜黑色素瘤中发生的染色体、基因和分子改变的理解取得了令人瞩目的进展。然而，这种眼癌分子发病机制的连贯图景尚未形成。在此，我们回顾迄今为止的研究结果，讨论它们所提供的见解，并提出葡萄膜黑色素瘤分子研究的未来方向。