少即是多：抑制自发放电可引发兴奋性的持续增加。

Less means more: inhibition of spontaneous firing triggers persistent increases in excitability.

作者信息

Häusser Michael, Monsivais Pablo

机构信息

Wolfson Institute for Biomedical Research, University College London, Gower Street, WC1E 6BT London, United Kingdom.

出版信息

Neuron. 2003 Oct 30;40(3):449-51. doi: 10.1016/s0896-6273(03)00686-x.

DOI:10.1016/s0896-6273(03)00686-x

PMID:14642267

Abstract

Modulation of intrinsic excitability is an alternative to classical synaptic plasticity for implementing activity-dependent changes in neuronal networks. In this issue of Neuron, Nelson et al. reveal a new form of plasticity of intrinsic excitability that can be triggered rapidly when synaptic inhibition reduces spontaneous firing, resulting in persistent enhancement of firing rate and neuronal gain.

摘要

内在兴奋性的调节是实现神经网络中活动依赖性变化的一种替代经典突触可塑性的方式。在本期《神经元》杂志中，纳尔逊等人揭示了一种内在兴奋性可塑性的新形式，当突触抑制降低自发放电时，这种新形式的可塑性能够快速触发，从而导致放电率和神经元增益的持续增强。