单核非血红素铁酶的功能模型

Functional models for mononuclear nonheme iron enzymes.

作者信息

Rohde Jan-Uwe, Bukowski Michael R, Que Lawrence

机构信息

Department of Chemistry and Center for Metals in Biocatalysis, University of Minnesota, 207 Pleasant Street SE, Minneapolis, MN 55455, USA.

出版信息

Curr Opin Chem Biol. 2003 Dec;7(6):674-82. doi: 10.1016/j.cbpa.2003.10.008.

DOI:10.1016/j.cbpa.2003.10.008

PMID:14644175

Abstract

Increasing interest in mononuclear nonheme iron enzymes that activate dioxygen has resulted in an explosion of information on such enzymes in recent years. Concomitantly, efforts to model the active sites of these enzymes have produced synthetic complexes capable of mimicking some aspect of the reactivity of the metal center in several enzymes. These functional models carry out oxidative transformations analogous to those catalyzed by the enzymes and in some cases allow iron(III)-peroxo or iron(IV)-oxo intermediates to be trapped and characterized.

摘要

近年来，人们对激活双氧的单核非血红素铁酶越来越感兴趣，这导致了近年来关于此类酶的信息激增。与此同时，对这些酶活性位点进行模拟的努力产生了一些合成配合物，它们能够模拟几种酶中金属中心反应性的某些方面。这些功能模型能够进行类似于酶催化的氧化转化，在某些情况下，还能捕获并表征铁（III）-过氧或铁（IV）-氧中间体。