Tantisira K G, Litonjua A A, Weiss S T, Fuhlbrigge A L
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Thorax. 2003 Dec;58(12):1036-41. doi: 10.1136/thorax.58.12.1036.
While increases in body mass index (BMI) have been associated with the incidence and prevalence of asthma, the mechanisms behind this association are unclear.
We hypothesised that BMI would be independently associated with measures of asthma severity in a population of children with mild to moderate asthma enrolled in the Childhood Asthma Management Program (CAMP). A multivariable baseline cross sectional analysis of BMI with our outcomes of interest was performed.
BMI was generally not associated with symptoms, nor was it associated with atopy. While BMI was positively associated with the methacholine concentration that causes a 20% fall in forced expiratory volume in 1 second (PC(20)FEV(1)), this association did not persist after adjustment for FEV(1). Increasing BMI was associated with increasing FEV(1) (beta = 0.006 l, 95% CI (0.001 to 0.01)) and forced vital capacity (FVC) (beta = 0.012 l, 95% CI (0.007 to 0.017)). However, decrements in the FEV(1)/FVC ratio were noted with increasing BMI (beta = -0.242, 95% CI (-0.118 to -0.366)). Thus, an increase in BMI of 5 units was associated with a decrease in FEV(1)/FVC of over 1%.
Although the association of FEV(1) and FVC with BMI did not support our initial hypothesis, the decrease noted in the FEV(1)/FVC ratio has potential relevance in the relationship between BMI and asthma severity.
虽然体重指数（BMI）的增加与哮喘的发病率和患病率相关，但其背后的机制尚不清楚。
我们假设，在参加儿童哮喘管理项目（CAMP）的轻至中度哮喘儿童群体中，BMI将独立与哮喘严重程度指标相关。对BMI与我们感兴趣的结果进行了多变量基线横断面分析。
BMI一般与症状无关，也与特应性无关。虽然BMI与使一秒用力呼气量（FEV₁）下降20%的乙酰甲胆碱浓度呈正相关，但在对FEV₁进行校正后，这种相关性不再存在。BMI增加与FEV₁增加（β = 0.006升，95%可信区间（0.001至0.01））和用力肺活量（FVC）增加（β = 0.012升，95%可信区间（0.007至0.017））相关。然而，随着BMI增加，FEV₁/FVC比值下降（β = -0.242，95%可信区间（-0.118至-0.366））。因此，BMI增加5个单位与FEV₁/FVC下降超过1%相关。
虽然FEV₁和FVC与BMI的相关性不支持我们最初的假设，但FEV₁/FVC比值下降在BMI与哮喘严重程度的关系中具有潜在相关性。
