Maksoud-Filho J G, Diniz E M, Ceccon M E, Galvani A L, Chamelian M D, Pinho M L, Vaz F A
Universidade de São Paulo (USP), SP, Brazil.
J Pediatr (Rio J). 2001 May-Jun;77(3):243-8. doi: 10.2223/jped.212.
To present the clinical outcome of a newborn with severe respiratory distress secondary to meconium aspiration syndrome and treated by extracorporeal membrane oxygenation (ECMO); and to present the effect of the use of exogenous surfactant in this case and the cost of the procedure. METHODS: Case report of a newborn with meconium aspiration syndrome and treated at the neonatal ICU of the Instituto da Criança Prof. Pedro de Alcantara, Hospital das Clínicas of the Universidade de São Paulo. RRESULTS: ECMO was carried out for 5 days with no clinical or mechanical complications. On the 4th day of ECMO, we administered porcine exogenous surfactant; a significant improvement in lung compliance was observed and the newborn was decannulated shortly after that. Treatment costs were compatible with the situation of healthcare in Brazil for treatment of critically ill newborn patients. CONCLUSIONS: ECMO is indicated in cases of neonatal respiratory distress not responding to other treatments. The technique should be made available in neonatal Intensive Care Units (ICUs) of tertiary hospitals according to well-established protocols. The use of exogenous surfactant apparently allowed for earlier decannulation of the patient and should be considered in similar cases. The treatment costs do justify the organizing of ECMO teams in this type of ICUs.
介绍一名因胎粪吸入综合征继发严重呼吸窘迫并接受体外膜肺氧合(ECMO)治疗的新生儿的临床结局;并介绍本例中使用外源性表面活性剂的效果及该治疗过程的费用。方法:对一名患有胎粪吸入综合征并在圣保罗大学临床医院佩德罗·德阿尔坎塔拉教授儿童医院新生儿重症监护病房接受治疗的新生儿进行病例报告。结果:ECMO治疗持续了5天,无临床或机械并发症。在ECMO治疗的第4天,我们给予了猪源性外源性表面活性剂;观察到肺顺应性有显著改善,新生儿随后不久拔除了插管。治疗费用与巴西治疗危重新生儿患者的医疗保健情况相符。结论:对于对其他治疗无反应的新生儿呼吸窘迫病例,ECMO是适用的。应根据既定方案在三级医院的新生儿重症监护病房(ICU)开展这项技术。外源性表面活性剂的使用显然使患者能够更早拔除插管,在类似病例中应予以考虑。治疗费用确实证明在这类ICU中组建ECMO团队是合理的。