[E-钙黏蛋白基因蛋白在口腔疣状癌中的表达]
[Expression of E-cadherin gene protein in oral verrucous carcinoma].
作者信息
Tang Zhan-gui, Zou Ping, Xie Xiao-li
机构信息
Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, Changsha 410078, China.
出版信息
Hunan Yi Ke Da Xue Xue Bao. 2003 Jun;28(3):206-8.
OBJECTIVE
To determine the relationship between E-cadherin over-expression and progression in oral verrucous carcinoma.
METHODS
Immunohistochemistry assay was performed on 12 cases of oral verrucous carcinoma (VC) and 20 cases of oral squamous epithelial cells carcinoma (SCC) using monoclonal antibody against E-cadherin gene protein.
RESULTS
The E-cadherin positive expression in VC (83.3%) was significantly higher than that in the poorly differentiated SCC(37.5%; P < 0.05), but the negative expression of E-cadherin in VC was between the well differentiated squamous cell carcinoma and the poorly differentiated squamous cell carcinoma.
CONCLUSION
E-cadherin over-expression plays an important role in oral verrucous carcinoma.
目的
确定E-钙黏蛋白过表达与口腔疣状癌进展之间的关系。
方法
采用抗E-钙黏蛋白基因蛋白单克隆抗体，对12例口腔疣状癌（VC）和20例口腔鳞状上皮细胞癌（SCC）进行免疫组织化学检测。
结果
VC中E-钙黏蛋白阳性表达率（83.3%）显著高于低分化SCC（37.5%；P<0.05），但VC中E-钙黏蛋白阴性表达介于高分化鳞状细胞癌和低分化鳞状细胞癌之间。
结论
E-钙黏蛋白过表达在口腔疣状癌中起重要作用。
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