磺基保护的己糖胺单糖：糖胺聚糖合成中潜在的多功能构建块。
Sulfo-protected hexosamine monosaccharides: potentially versatile building blocks for glycosaminoglycan synthesis.
作者信息
Karst Nathalie A, Islam Tasneem F, Linhardt Robert J
机构信息
Departments of Chemistry, Biology and Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
出版信息
Org Lett. 2003 Dec 11;5(25):4839-42. doi: 10.1021/ol035882w.
2,2,2-Trifluorodiazoethane was investigated as a reagent for sulfo group protection on hexosamine monosaccharides. The synthesis of glucosamine and galactosamine building blocks fully differentiated for glycosaminoglycan synthesis and the synthesis of glycosyl donors are described. The compatibility of trifluoroethylsulfonate under a variety of reaction conditions has also been investigated. [structure: see text]
研究了2,2,2-三氟重氮乙烷作为己糖胺单糖上磺酸基保护试剂的性能。描述了用于糖胺聚糖合成的完全差异化的葡萄糖胺和半乳糖胺结构单元的合成以及糖基供体的合成。还研究了三氟乙基磺酸盐在各种反应条件下的兼容性。[结构：见正文]
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