大鼠运动神经纤维中的乙酰胆碱酯酶活性与肌纤维类型的相关性

Acetylcholinesterase activity in motor nerve fibres in correlation to muscle fibre types in rat.

作者信息

Gruber H, Zenker W

出版信息

Brain Res. 1978 Feb 10;141(2):325-34. doi: 10.1016/0006-8993(78)90201-9.

Abstract

Rat muscle nerves were examined histochemically for their activity of acetylcholinesterase (AChE). The corresponding muscles were stained for myofibrillar ATPase and for NADH diaphorase. The nerves to the extensor digitorum longus (EDL) muscle and to the medial head of the gastrocnemius (MG) muscle consist of a motor axons of high AChE activity. Both muscles are characterized by the prevalence of type II muscle fibres. On the other hand, the soleus muscle and the quandratus femoris muscle, both mainly composed of type I muscle fibres, are innervated by a motor axons of low AChE activity. Since it is well established that EDL and MG are typical fast-twitch muscles and that the soleus, and probably also the auadratus femoris, is a typical slow-twitch muscle, it is suggested that, in rat, fast muscles are innervated by motor nerve fibres of high AChE activity and slow muscles are innervated by motor axons of low AChE activity.

摘要

对大鼠肌肉神经进行了乙酰胆碱酯酶（AChE）活性的组织化学检查。对相应的肌肉进行了肌原纤维ATP酶和NADH黄递酶染色。支配趾长伸肌（EDL）和腓肠肌内侧头（MG）的神经由高AChE活性的运动轴突组成。这两块肌肉均以II型肌纤维为主。另一方面，比目鱼肌和股四头肌主要由I型肌纤维组成，它们由低AChE活性的运动轴突支配。由于已经明确EDL和MG是典型的快肌，比目鱼肌以及可能的股四头肌是典型的慢肌，因此表明，在大鼠中，快肌由高AChE活性的运动神经纤维支配，慢肌由低AChE活性的运动轴突支配。