Downward Julian
Signal Transduction Laboratory, Cancer Research UK London Research Institute, UK.
Biochem J. 2003 Dec 15;376(Pt 3):e9-10. doi: 10.1042/BJ20031745.
Ras protein regulation by G-protein-coupled receptors has been thought to occur through transactivation of receptor tyrosine kinases. New evidence suggests that these two receptor types independently control different pathways leading to Ras activation in response to lysophosphatidic acid (LPA). Epidermal growth factor receptor function is needed for basal nucleotide exchange on Ras, whereas the LPA receptor controls an inducible exchange activity.
G蛋白偶联受体对Ras蛋白的调节一直被认为是通过受体酪氨酸激酶的反式激活来实现的。新证据表明,这两种受体类型独立控制不同的通路,导致在溶血磷脂酸(LPA)作用下Ras激活。Ras上的基础核苷酸交换需要表皮生长因子受体发挥功能,而LPA受体则控制一种可诱导的交换活性。