在山羊怀孕的不同阶段用山羊疱疹病毒1进行实验性感染。

Experimental infection of goats at different stages of pregnancy with caprine herpesvirus 1.

作者信息

Tempesta M, Camero M, Sciorsci R L, Greco G, Minoia R, Martella V, Pratelli A, Buonavoglia C

机构信息

Faculty of Veterinary Medicine, Department of Health and Animal Welfare, University of Bari, Strada provinciale per Casamassima km 3, Valenzano, 70010, Bari, Italy.

出版信息

Comp Immunol Microbiol Infect Dis. 2004 Jan;27(1):25-32. doi: 10.1016/S0147-9571(03)00012-2.

DOI:10.1016/S0147-9571(03)00012-2

PMID:14656539

Abstract

Three goats from a group of five caprine herpesvirus 1 (CpHV.1) seronegative pregnant goats were inoculated intranasally with a virulent BA.1 strain of CpHV.1. Goat n.1 was infected on day 45 of pregnancy, goat n.2 on day 92 and goat n.3 on day 127. Each of the three goats produced a single foetus 10-60 days after infection. Foetus n.1 was never found and so it could not be examined for virological findings. Goat n.2 delivered at term of gestation and CpHV.1 was detected by PCR and isolated from most of the foetal organs. Foetus n.3 was partially autolysed and the virus was only detected by PCR but not isolated from foetal organs. The results confirm the damaging effect of CpHV.1 infection on pregnancy, the difficulty in diagnosing the CpHV.1 induced abortion, and the importance developing appropriate prophylactic programmes.

摘要

从一组五只血清学检测为阴性的妊娠山羊中选取三只，经鼻内接种了强毒株CpHV.1 BA.1。山羊1号在妊娠第45天感染，山羊2号在第92天感染，山羊3号在第127天感染。三只山羊在感染后10 - 60天均产下一只胎儿。未找到胎儿1号，因此无法对其进行病毒学检查。山羊2号足月分娩，通过PCR检测到CpHV.1，并从大部分胎儿器官中分离出该病毒。胎儿3号部分自溶，仅通过PCR检测到病毒，未从胎儿器官中分离出病毒。结果证实了CpHV.1感染对妊娠的破坏作用、诊断CpHV.1诱导流产的困难以及制定适当预防方案的重要性。