Ivić M A, Bogićević M, Djordjević V, Mitić M, Stefanović V
Institute of Nephrology and Haemodialysis, Nis.
Srp Arh Celok Lek. 1992 May-Jun;120(5-6):141-5.
The circadian rhythms of the serum immunoreactive parathyroid hormone (iPTH) and calcitonin concentration were examined in 6 patients with chronic renal failure (CRF) not treated by haemodialysis. In 3 patients on haemodialysis the influence of haemodialysis with cuprophan and polyacrylonitrile membranes (in a.m. and p.m. periods of day) on serum concentration of these was investigated. The results demonstrate that in patients with CRF in predialysis period the circadian rhythm of serum iPTH concentration is at least partially preserved. However, the effect of dialysis on serum C-terminal iPTH concentration showed a sharp progressive fall of the concentration during haemodialysis on polyacrylonitrile membranes. The study of the circadian rhythm of serum calcitonin concentration in CRF patients with the six hours intervals between blood sampling could not reveal changes which favour the opinion of the existence of circadian rhythmicity. In patients on haemodialysis during haemodialysis with cuprophan membranes a rise of serum calcitonin concentration was observed.
对6例未接受血液透析治疗的慢性肾衰竭（CRF）患者的血清免疫反应性甲状旁腺激素（iPTH）和降钙素浓度的昼夜节律进行了研究。对3例接受血液透析的患者，研究了用铜仿膜和聚丙烯腈膜进行血液透析（在上午和下午时段）对这些物质血清浓度的影响。结果表明，在CRF患者的透析前期，血清iPTH浓度的昼夜节律至少部分得以保留。然而，透析对血清C端iPTH浓度的影响显示，在使用聚丙烯腈膜进行血液透析期间，该浓度急剧下降。对CRF患者每6小时采血一次以研究血清降钙素浓度的昼夜节律，未发现支持昼夜节律存在观点的变化。在使用铜仿膜进行血液透析的患者中，观察到血清降钙素浓度升高。
