Desreux J, Kebers F, Noël A, Francart D, Van Cauwenberge H, Heinen V, Peyrollier K, Thomas J L, Bernard A M, Paris J, Delansorne R, Foidart J M
Laboratory of Tumor and Development Biology, University Hospital, University of Liege, Sart Tilman, B-4000 Liege, Belgium.
Breast. 2003 Apr;12(2):142-9. doi: 10.1016/s0960-9776(03)00003-1.
Many investigators have reported cyclic proliferation of normal human breast epithelial cells. A delicate balance between proliferation and apoptosis (programmed cell death) ensures breast homeostasis. Both the follicular and luteal phases of the menstrual cycle are characterized by proliferation, whereas apoptosis occurs only at the end of the latter phase. In this study, we observed that the withdrawal of a synthetic progestin (nomegestrol acetate or NOMAC), but not continuous treatment with it, induced apoptosis of normal human breast epithelial cells in vitro and in women who applied NOMAC gel to their breasts. Furthermore, this apoptotic response was specific to normal breast cells, since withdrawal of NOMAC did not induce apoptosis of tumoral T47D cells in vitro or of fibroadenoma cells in women. These observations open up new perspectives in the prevention of hyperplasia and breast cancer.
许多研究人员报告了正常人乳腺上皮细胞的周期性增殖。增殖与凋亡（程序性细胞死亡）之间的微妙平衡确保了乳腺的稳态。月经周期的卵泡期和黄体期均以增殖为特征，而凋亡仅发生在黄体期结束时。在本研究中，我们观察到，停用合成孕激素（醋酸诺美孕酮或NOMAC）而非持续使用它，可在体外以及在乳房涂抹NOMAC凝胶的女性体内诱导正常人乳腺上皮细胞凋亡。此外，这种凋亡反应是正常乳腺细胞特有的，因为停用NOMAC不会在体外诱导肿瘤性T47D细胞或女性纤维腺瘤细胞凋亡。这些观察结果为预防乳腺增生和乳腺癌开辟了新的前景。
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