Cvitkovitch Dennis G, Li Yung-Hua, Ellen Richard P
Room 449A, Dental Research Institute, University of Toronto, 124 Edward Street, Toronto, Ontario M5G 1G6, Canada.
J Clin Invest. 2003 Dec;112(11):1626-32. doi: 10.1172/JCI20430.
Members of the bacterial genus Streptococcus are responsible for causing a wide variety of infections in humans. Many Streptococci use quorum-sensing systems to regulate several physiological properties, including the ability to incorporate foreign DNA, tolerate acid, form biofilms, and become virulent. These quorum-sensing systems are primarily made of small soluble signal peptides that are detected by neighboring cells via a histidine kinase/response regulator pair.
链球菌属的细菌会导致人类多种感染。许多链球菌利用群体感应系统来调节多种生理特性,包括整合外源DNA的能力、耐酸性、形成生物膜以及变得具有毒性。这些群体感应系统主要由小的可溶性信号肽组成,相邻细胞通过组氨酸激酶/反应调节因子对来检测这些信号肽。