柔红霉素和米托蒽醌与急性髓系白血病患者红细胞的相互作用。
The interaction of daunorubicin and mitoxantrone with the red blood cells of acute myeloid leukemia patients.
作者信息
Marczak Agnieszka, Wrzesień-Kuś Agata, Krykowski Euzebiusz, Robak Tadeusz, Júźwiak Zofia
机构信息
Department of Thermobiology, University of Łódź, Banacha 12/16, 90-237 Łódź, Poland.
出版信息
Cell Mol Biol Lett. 2003;8(4):885-90.
The effect of DNR and MIT on erythrocyte membrane structure was examined using Electron Spin Resonance spectroscopy and the fluorimetric technique. The results suggest that the in vivo interaction of the drugs with the RBCs of AML patients led to a perturbation in the structure of plasma membrane components. Differences between DNR and MIT were only noted in the interaction of the drugs with deeper regions of the lipid bilayer
使用电子自旋共振光谱法和荧光技术研究了柔红霉素（DNR）和米托蒽醌（MIT）对红细胞膜结构的影响。结果表明，药物在体内与急性髓系白血病（AML）患者的红细胞相互作用导致质膜成分结构发生扰动。仅在药物与脂质双层较深区域的相互作用中发现了柔红霉素和米托蒽醌之间的差异。
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