Obara Kenji, Komeyama Takeshi, Mizusawa Takaki, Tsutsui Toshiki, Wakatsuki Hidemitsu, Arai Kei, Kosegawa Etsuko, Suzuki Kazuya, Takahashi Kota
Division of Urology, Department of Regenerative and Transplant Medicine, Course of Biological Function and Medical Control, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Nihon Hinyokika Gakkai Zasshi. 2003 Nov;94(7):664-70. doi: 10.5980/jpnjurol1989.94.664.
The aim of current study was to review the consequence after introduction of clean intermittent catheterization (CIC) in children with neurogenic bladder dysfunction secondary to spina bifida.
We retrospectively reviewed the records of 34 children (19 girls and 15 boys) presenting our clinic in a 18-year period. The patients were divided concentrating on the radiological upper urinary tract findings when CIC was introduced. 18 children had dilated upper urinary tract. In these patients, 10 children already had dilated upper urinary tract at first visiting to our clinic(group A). In remaining 8 patients, dilatation of upper urinary tract was found out in the course of followup (group B). 16 children had normal upper urinary tract when CIC was introduced. In 7 patients, CIC was applied for post-void residual and urinary tract infection (group C). In remaining 9 patients, CIC was introduced for urodynamically low compliance bladder (group D).
In group A, 5 patients underwent enterocystoplasty and 3 patients underwent anti-reflux surgery consequently. Two patients, including 1 patient who underwent enterocystoplasty, have chronic renal dysfunction. In group B, 3 patients underwent enterocystoplasty and 2 patients underwent anti-reflux surgery. In group C, all patients have normal upper urinary tract. In group D, 8 patients have normal upper urinary tract. However, 1 patients underwent enterocystoplasty for low compliance bladder with vesicoureteral reflux (VUR).
Some patients show the improvement of dilated upper urinary tract or VUR after introduction of CIC. However, enterocystoplasty or anti-reflux surgery was needed for many patients to prevent upper urinary tract deterioration. The patients whom CIC was introduced for postvoid residual and urinary tract infection have not shown any deterioration of upper urinary tract. The efficacy of CIC for incontinence was poor because many patients have urethral sphincter incompetence.
本研究旨在回顾脊柱裂继发神经源性膀胱功能障碍患儿采用清洁间歇性导尿(CIC)后的结果。
我们回顾性分析了18年间在我院就诊的34例患儿(19例女孩和15例男孩)的病历。根据导尿开始时的放射学上尿路检查结果将患者分组。18例患儿存在上尿路扩张。在这些患者中,10例患儿初诊时就已存在上尿路扩张(A组)。其余8例患者在随访过程中发现上尿路扩张(B组)。16例患儿导尿开始时上尿路正常。7例患者因残余尿量和尿路感染采用导尿(C组)。其余9例患者因尿动力学检查显示膀胱顺应性低而采用导尿(D组)。
A组中,5例患者接受了肠膀胱扩大术,3例患者随后接受了抗反流手术。2例患者,包括1例接受肠膀胱扩大术的患者,患有慢性肾功能不全。B组中,3例患者接受了肠膀胱扩大术,2例患者接受了抗反流手术。C组所有患者上尿路正常。D组8例患者上尿路正常。然而,1例患者因膀胱顺应性低合并膀胱输尿管反流(VUR)接受了肠膀胱扩大术。
部分患者采用导尿后上尿路扩张或VUR有所改善。然而,许多患者需要接受肠膀胱扩大术或抗反流手术以防止上尿路恶化。因残余尿量和尿路感染而采用导尿的患者上尿路未出现任何恶化。由于许多患者存在尿道括约肌功能不全,导尿对尿失禁的疗效较差。