晚期卵巢癌的最佳治疗方案：卡铂与紫杉醇对比顺铂与紫杉醇（妇科肿瘤学组158号研究）及妇科肿瘤学组182号研究-国际卵巢癌协作组5号研究的最新进展
Optimal therapy of advanced ovarian cancer: carboplatin and paclitaxel vs. cisplatin and paclitaxel (GOG 158) and an update on GOG0 182-ICON5.
作者信息
Bookman M A, Greer B E, Ozols R F
机构信息
Division of Medical Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.
出版信息
Int J Gynecol Cancer. 2003 Nov-Dec;13(6):735-40. doi: 10.1111/j.1525-1438.2003.13602.x.
Mature results from GOG158 have clearly established carboplatin and paclitaxel as an effective and well tolerated standard regimen, providing a basis for the reference arm in GOG0182-ICON5, an ongoing multiarmed phase III trial of the Gynecologic Cancer InterGroup (GCIG) evaluating the incorporation of newer cytotoxic agents. Results from GOG158 will be reviewed, including an analysis of second-look surgical outcomes, followed by an update on the current status of GOG0182-ICON5.
妇科肿瘤学组（GCIG）正在进行的一项多臂III期试验GOG0182-ICON5旨在评估新型细胞毒性药物的加入情况，而GOG158的成熟结果已明确确立卡铂和紫杉醇是一种有效且耐受性良好的标准方案，为该试验的对照臂提供了参考依据。将对GOG158的结果进行回顾，包括二次探查手术结果分析，随后更新GOG0182-ICON5的当前状态。
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