Li Li-bo, Luo Rong-cheng, Liao Wang-jun, Zhang Ming-jiang, Zhou Jin, Liu Xiao-jun, Miao Jing-xia
Department of Oncology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
Di Yi Jun Yi Da Xue Xue Bao. 2003 Dec;23(12):1341-3.
To evaluate the clinical efficacy and adverse effects of Photofrin photodynamic therapy (PDT) in patients with advanced cancers.
Forty patients with advanced cancers in stage IV with lumen obstruction, who failed to respond positively to other treatment regimens, received intravenous administration of Photofrin as the photosensitizer at the dose of 2 mg/kg.b.w. 48 h before PDT by 630 nm light (DIOMED) delivered through cylinder diffusing tip quartz fibers that passed through the biopsy channel of a flexible endoscope. PDT endoscopy was repeated, the necrotic tissue removed and, if necessary, the primary sites and other newly identified sites were subjected to a second exposure 8 h later. Two days after the second exposure, endoscopy was again performed and the necrotic tissue removed. Endoscopy was repeated one month after PDT and periodically thereafter as needed to treat symptomatic residual tumor.
The total rate of response to the treatment was 74% in these patients, and the rate of lumen obstruction due to the tumors decreased from 90% to 10% after PDT, with significantly improved Karnofsky performance score.
Photofrin PDT is effective and safe in the treatment of advanced cancer, which may relieve lumen obstruction and improve patient quality of life.
评估光卟啉光动力疗法（PDT）对晚期癌症患者的临床疗效及不良反应。
40例IV期晚期癌症且伴有管腔阻塞、对其他治疗方案无阳性反应的患者，在PDT前48小时静脉注射光卟啉作为光敏剂，剂量为2mg/kg体重。通过穿过柔性内窥镜活检通道的圆柱形扩散头石英纤维，用630nm光（DIOMED）进行PDT。重复进行PDT内镜检查，清除坏死组织，如有必要，8小时后对原发部位和其他新发现部位进行第二次照射。第二次照射两天后，再次进行内镜检查并清除坏死组织。PDT后1个月重复进行内镜检查，此后根据需要定期进行，以治疗有症状的残留肿瘤。
这些患者的总治疗有效率为74%，PDT后肿瘤导致的管腔阻塞率从90%降至10%，卡诺夫斯基性能评分显著提高。
光卟啉PDT治疗晚期癌症有效且安全，可缓解管腔阻塞，提高患者生活质量。
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