Echániz Avilés G, Conde González C, Juárez Figueroa L, Carnalla Barajas N, Tamayo Legorreta E, Calderón Jaimes E
Center for Research on Infectious Diseases, National Institute of Public Health of Mexico, Cuernavaca, Morelos.
Clin Ther. 1992 Sep-Oct;14(5):688-95.
The increasing resistance of genital mycoplasmas to tetracyclines is a serious problem, since this group of antibiotics is one of the few that is effective against virtually all species of mycoplasmas. Tetracyclines are also used to treat many sexually transmitted diseases. In this study, we assessed the susceptibility of Mycoplasma hominis and Ureaplasma urealyticum to macrolides, tetracyclines, spectinomycin, and trospectomycin by the agar dilution method. For M hominis, trospectomycin was the most active agent. Spectinomycin, tetracycline, and doxycycline had comparable mycoplasmatic activity, and the macrolides were ineffective. Against U urealyticum, spectinomycin and trospectomycin were the most active drugs, and were at least twofold more active than the macrolides and tetracyclines.
生殖支原体对四环素的耐药性不断增加是一个严重问题，因为这类抗生素是少数对几乎所有支原体物种都有效的药物之一。四环素还用于治疗许多性传播疾病。在本研究中，我们通过琼脂稀释法评估了人型支原体和解脲脲原体对大环内酯类、四环素类、大观霉素和曲古抑菌素的敏感性。对于人型支原体，曲古抑菌素是最有效的药物。大观霉素、四环素和多西环素具有相当的支原体活性，而大环内酯类无效。对于解脲脲原体，大观霉素和曲古抑菌素是最有效的药物，其活性至少比大环内酯类和四环素类高两倍。
