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二酰甘油酰基转移酶:肥胖症和2型糖尿病的新型治疗靶点。

DGAT: novel therapeutic target for obesity and type 2 diabetes mellitus.

作者信息

Subauste Angela, Burant Charles F

机构信息

Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

出版信息

Curr Drug Targets Immune Endocr Metabol Disord. 2003 Dec;3(4):263-70. doi: 10.2174/1568008033340081.

Abstract

Obesity is currently an exceptionally common problem in humans. The last several years have produced a significant number of breakthroughs in obesity related areas of investigation. Triglycerides are considered the main form of storage of excess calories in fat. A key enzyme in the synthesis of triglycerides is acylCoA: diacylglycerol acyltransferase (DGAT). Recent studies have shown that mice deficient in this enzyme are resistant to diet induced obesity and have increased insulin and leptin sensitivity. These effects suggest that inhibition of DGAT in vivo may be a novel therapeutic target not only for obesity but also for diabetes.

摘要

肥胖目前是人类中极为常见的问题。在过去几年里,肥胖相关研究领域取得了大量重大突破。甘油三酯被认为是多余热量在脂肪中储存的主要形式。甘油三酯合成中的一种关键酶是酰基辅酶A:二酰甘油酰基转移酶(DGAT)。最近的研究表明,缺乏这种酶的小鼠对饮食诱导的肥胖具有抗性,并且胰岛素和瘦素敏感性增加。这些效应表明,体内抑制DGAT不仅可能是肥胖的一种新型治疗靶点,也是糖尿病的新型治疗靶点。

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