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Neuroscience. ORs rule the roost in the olfactory system.

作者信息

Lewcock Joseph W, Reed Randall R

机构信息

Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

出版信息

Science. 2003 Dec 19;302(5653):2078-9. doi: 10.1126/science.1093397.

DOI:10.1126/science.1093397

PMID:14684811

Abstract

摘要

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Neuroscience. ORs rule the roost in the olfactory system.

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Olfactory receptor genes expressed in distinct lineages are sequestered in different nuclear compartments.

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Functional interrogation of an odorant receptor locus reveals multiple axes of transcriptional regulation.

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相似文献

Neuroscience. ORs rule the roost in the olfactory system.

Science. 2003 Dec 19;302(5653):2078-9. doi: 10.1126/science.1093397.

Negative feedback regulation ensures the one receptor-one olfactory neuron rule in mouse.

Science. 2003 Dec 19;302(5653):2088-94. doi: 10.1126/science.1089122. Epub 2003 Oct 30.

Blurring cis and trans in gene regulation.

Cell. 2006 Jul 28;126(2):248-50. doi: 10.1016/j.cell.2006.07.008.

Interchromosomal interactions and olfactory receptor choice.

Cell. 2006 Jul 28;126(2):403-13. doi: 10.1016/j.cell.2006.06.035.

The OMP-lacZ transgene mimics the unusual expression pattern of OR-Z6, a new odorant receptor gene on mouse chromosome 6: implication for locus-dependent gene expression.

J Neurosci. 2001 Jul 1;21(13):4637-48. doi: 10.1523/JNEUROSCI.21-13-04637.2001.

Regulation of odorant receptors: one allele at a time.

Hum Mol Genet. 2005 Apr 15;14 Spec No 1:R33-9. doi: 10.1093/hmg/ddi105.

YAC transgene-mediated olfactory receptor gene choice.

Dev Dyn. 2000 Feb;217(2):225-31. doi: 10.1002/(SICI)1097-0177(200002)217:2<225::AID-DVDY9>3.0.CO;2-3.

The promoter of the mouse odorant receptor gene M71.

Mol Cell Neurosci. 2005 Mar;28(3):535-46. doi: 10.1016/j.mcn.2004.11.006.

Olfactory receptor genes expressed in distinct lineages are sequestered in different nuclear compartments.

Proc Natl Acad Sci U S A. 2015 May 5;112(18):E2403-9. doi: 10.1073/pnas.1506058112. Epub 2015 Apr 20.

One neuron-one receptor rule in the mouse olfactory system.

Trends Genet. 2004 Dec;20(12):648-53. doi: 10.1016/j.tig.2004.09.006.

引用本文的文献

Functional interrogation of an odorant receptor locus reveals multiple axes of transcriptional regulation.

PLoS Biol. 2013;11(5):e1001568. doi: 10.1371/journal.pbio.1001568. Epub 2013 May 21.

Response enhancement of olfactory sensory neurons-based biosensors for odorant detection.

J Zhejiang Univ Sci B. 2009 Apr;10(4):285-90. doi: 10.1631/jzus.B0820220.

Deletion of the core-H region in mice abolishes the expression of three proximal odorant receptor genes in cis.

Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):20067-72. doi: 10.1073/pnas.0706544105. Epub 2007 Dec 5.

Zfp423/OAZ participates in a developmental switch during olfactory neurogenesis.

Neuron. 2007 May 24;54(4):547-57. doi: 10.1016/j.neuron.2007.04.029.

Neuroscience. ORs rule the roost in the olfactory system.

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