Sen Seema, Kashyap Seema, Betharia Subhash
Department of Ocular Pathology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Orbit. 2003 Dec;22(4):317-9. doi: 10.1076/orbi.22.4.317.17244.
A 50-year-old man presented with a fungating growth in the left eye of 3 months duration. Biopsy of the mass followed by light microscopy was suggestive of plasmacytoma and the diagnosis was confirmed by immunohistochemical stains, which demonstrated monoclonality to kappa light chains. Systemic investigations ruled out a multiple myeloma. The patient received radiotherapy; however, due to a residual mass, the left orbit had to be exenterated. Solitary plasmacytomas may not always be completely radiosensitive and radical surgery may be required in such cases. Immunohistochemical stains for kappa and lambda light chains can prove useful in confirming the diagnosis of suspected plasmacytomas.
一名50岁男性,左眼出现溃疡性肿物3个月。对肿物进行活检并经光学显微镜检查提示为浆细胞瘤,免疫组化染色证实了该诊断,显示κ轻链呈单克隆性。全身检查排除了多发性骨髓瘤。患者接受了放疗;然而,由于残留肿物,不得不对左眼眶进行眶内容剜除术。孤立性浆细胞瘤并非总是对放疗完全敏感,在这种情况下可能需要进行根治性手术。κ和λ轻链的免疫组化染色有助于确诊疑似浆细胞瘤。