Nahid Mohebbian, Bottenberg Peter
Département de Dentisterie Restauratrice, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Bruxelles.
Rev Belge Med Dent (1984). 2003;58(3):189-96.
The need for biocompatible materials implies the necessity of toxicity testing. The toxicity of a dental material can be evaluated by in vitro tests, by animal experimentation including usage tests, and by clinical studies in humans. In vitro studies are mainly performed to evaluate the cytotoxicity (cell damage) or the genotoxicity (specific DNA damage or chromosomal aberration) of a dental material. Cell or tissue cultures play an important role because they allow a maximum standardization. This paper describes their application and interpretation of results in biocompatibility tests.
对生物相容性材料的需求意味着进行毒性测试的必要性。牙科材料的毒性可通过体外测试、包括使用测试在内的动物实验以及人体临床研究来评估。体外研究主要用于评估牙科材料的细胞毒性（细胞损伤）或遗传毒性（特定的DNA损伤或染色体畸变）。细胞或组织培养起着重要作用，因为它们能实现最大程度的标准化。本文描述了它们在生物相容性测试中的应用及结果解读。
