Murphy Blake, Krieger Charles, Hoffer Joaquin-Andres
School of Kinesiology, Simon Fraser University, Burnaby, BC, Canada V5A 1S6.
J Neurosci Methods. 2004 Jan 15;132(1):25-33. doi: 10.1016/j.jneumeth.2003.08.013.
Implanted epineural electrodes were used for the longitudinal assessment of peripheral nerve conduction velocity (NCV) and compound action potential (CAP) amplitude in rats. Custom-fabricated stimulating and recording electrodes were sutured over the tibial and sciatic nerves, respectively, and were used for weekly recordings of CAP latency and amplitude. Intra-day variability of nerve conduction velocity measurements had coefficients of variation of less than 2% for same day recordings from individual subjects. A clear trend in recovery of the NCV values following implant was observed over the 7-week trial period. These results demonstrate that implanted epineural electrodes provide a reliable method for chronic, in vivo monitoring of nerve conduction parameters in rodents.
植入式神经外膜电极用于对大鼠外周神经传导速度（NCV）和复合动作电位（CAP）幅度进行纵向评估。定制的刺激电极和记录电极分别缝合在胫神经和坐骨神经上，用于每周记录CAP潜伏期和幅度。对于个体受试者同一天的记录，神经传导速度测量的日内变异性变异系数小于2%。在7周的试验期内，观察到植入后NCV值恢复的明显趋势。这些结果表明，植入式神经外膜电极提供了一种可靠的方法，用于在啮齿动物体内长期监测神经传导参数。
