锂中毒、高钙血症与“意外”诱发的食物和水厌恶：一例报告

Lithium intoxication, hypercalcemia and "accidentally" induced food and water aversion: a case report.

作者信息

Bilanakis Nikos, Gibiriti Mariana

机构信息

Psychiatric Clinic of University General Hospital of Ioannina, University Avenue, 19 Xanthou Str., 45500, Ioannina, Greece.

出版信息

Prog Neuropsychopharmacol Biol Psychiatry. 2004 Jan;28(1):201-3. doi: 10.1016/S0278-5846(03)00167-2.

DOI:10.1016/S0278-5846(03)00167-2

PMID:14687875

Abstract

Lithium is widely used in the management of patients with affective and other behavioral disorders. In addition to its therapeutic role, it is important to recognize that it occasionally causes severe side effects. Associated with its long-term use, parathyroid hypersecretion and hypercalcemia is a rare but reported side effect. A 54-year-old patient is reported who previously had a good response to lithium carbonate treatment of his bipolar disorder. Suddenly, and after 15 years of lithium carbonate use, he presented food and water aversion, hypercalcemia, lithium intoxication (SLi of 4.30 mmol/l) and acute renal insufficiency. Haemodialysis was carried out and the patient improved dramatically.

摘要

锂广泛应用于情感障碍和其他行为障碍患者的治疗。除了其治疗作用外，必须认识到它偶尔会引起严重的副作用。与其长期使用相关的甲状旁腺分泌过多和高钙血症是一种罕见但有报道的副作用。本文报告了一名54岁的患者，他之前接受碳酸锂治疗双相情感障碍效果良好。在使用碳酸锂15年后，他突然出现厌食物和水、高钙血症、锂中毒（血清锂为4.30 mmol/l）和急性肾功能不全。进行了血液透析，患者病情显著改善。